Melanie Z. Sakatis

Preclinical Strategy to Reduce Clinical Hepatotoxicity Using in Vitro Bioactivation Data for >200 Compounds

Melanie Z. Sakatis, Melinda J. Reese, Andrew W. Harrell et al. · Chemical Research in Toxicology · 2012 · 120 citations

System Pharmacology, Vitro Bioactivation Data, Pharmacodynamic Modeling +21

The discovery of fused pyrrole carboxylic acids as novel, potent d-amino acid oxidase (DAO) inhibitors

Tim Sparey, Pravien Abeywickrema, Sarah Almond et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 82 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Biochemistry +7

A quantitative high-throughput trapping assay as a measurement of potential for bioactivation

Georgina Meneses‐Lorente, Melanie Z. Sakatis, Timothy Schulz-Utermoehl et al. · Analytical Biochemistry · 2006 · 51 citations

Engineering, Biochemistry, Bioanalysis +10

An integrated reactive metabolite evaluation approach to assess and reduce safety risk during drug discovery and development

Melinda J. Reese, Melanie Z. Sakatis, Jeffrey L. Ambroso et al. · Chemico-Biological Interactions · 2010 · 29 citations

Drug Safety, Medicinal Chemistry, Safety Risk +12

Evaluation of a Three-Dimensional Primary Human Hepatocyte Spheroid Model: Adoption and Industrialization for the Enhanced Detection of Drug-Induced Liver Injury

Christopher Schofield, Tracy Walker, Maxine Taylor et al. · Chemical Research in Toxicology · 2021 · 21 citations

Pharmaceutical Research, Biomedical Engineering, Translational Medicine +26