Melanie Z. Sakatis

Preclinical Strategy to Reduce Clinical Hepatotoxicity Using in Vitro Bioactivation Data for >200 Compounds

Melanie Z. Sakatis, Melinda J. Reese, Andrew W. Harrell et al. · Chemical Research in Toxicology · 2012 · 121 citations

Pharmacy, Pharmacology, Toxicology +17

The discovery of fused pyrrole carboxylic acids as novel, potent d-amino acid oxidase (DAO) inhibitors

Tim Sparey, Pravien Abeywickrema, Sarah Almond et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 83 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

A quantitative high-throughput trapping assay as a measurement of potential for bioactivation

Georgina Meneses‐Lorente, Melanie Z. Sakatis, Timothy Schulz-Utermoehl et al. · Analytical Biochemistry · 2006 · 51 citations

Life Sciences, Biochemistry, Biosensors +7

An integrated reactive metabolite evaluation approach to assess and reduce safety risk during drug discovery and development

Melinda J. Reese, Melanie Z. Sakatis, Jeffrey L. Ambroso et al. · Chemico-Biological Interactions · 2010 · 29 citations

Pharmacy, Pharmacology, Toxicology +16

Considerations from an International Regulatory and Pharmaceutical Industry (IQ MPS Affiliate) Workshop on the Standardization of Complex In Vitro Models in Drug Development

Lindsay Tomlinson, Diane Ramsden, Sofia Batista Leite et al. · Advanced Biology · 2023 · 26 citations · Full text

Pharmacy, Pharmacology, Biopharmaceutics +12