C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

Andrew Epstein, Jonathan Gleadle, Luke A. McNeill, +17

Cell

Redox SignalingMolecular PhysiologyMammalian Homologs DefineRedox RegulatorNatural Sciences +9

Interleukin-1β and Tumor Necrosis Factor- Stimulate DNA Binding of Hypoxia-Inducible Factor-1

Thomas Hellwig‐Bürgel, Karen Rutkowski, Eric Metzen, +2

Blood

Intracellular localisation of human HIF-1α hydroxylases:implications for oxygen sensing

Eric Metzen, Utta Berchner‐Pfannschmidt, Petra Stengel, +9

Journal of Cell Science

Intracellular LocalisationReductive StressTranscriptional RegulationRedox SignalingOxygen Availability +13

Nitric Oxide Impairs Normoxic Degradation of HIF-1α by Inhibition of Prolyl Hydroxylases

Eric Metzen, Jie Zhou, Wolfgang Jelkmann, +2

Molecular Biology of the Cell

Nitric OxideRedox BiologyOxidative StressRedox RegulatorReactive Nitrogen Specie +18

Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-α-prolyl-4-hydroxylases

Jan H. Marxsen, Petra Stengel, Kathrin Doege, +6

Biochemical Journal

Interleukin-1β and Tumor Necrosis Factor- Stimulate DNA Binding of Hypoxia-Inducible Factor-1

Thomas Hellwig‐Bürgel, Karen Rutkowski, Eric Metzen, +2

Blood

Regulation of the prolyl hydroxylase domain protein 2 (<i>phd2</i>/<i>egln-1</i>) gene: identification of a functional hypoxia-responsive element

Eric Metzen, Daniel P. Stiehl, Kathrin Doege, +3

Biochemical Journal

Redox SignalingTranscriptional RegulationHypoxia-inducible FactorsBiochemistryCpg Island +13

Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain

Emma C. Vaux, Eric Metzen, Kay M. Yeates, +1

Blood

Pericellular PO2 and O2 consumption in monolayer cell cultures

Eric Metzen, Martin Wolff, Joachim Fandrey, +1

Respiration Physiology

Cell PhysiologyMembrane TransportCell CultureMedicineCell Biology +3

Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact

Kathrin Doege, Sandra Heine, Inga Jensen, +2

Blood