Eric Metzen

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

Andrew Epstein, Jonathan Gleadle, Luke A. McNeill et al. · Cell · 2001 · 3.3K citations · Full text

Redox Signaling, Molecular Physiology, Mammalian Homologs Define +11

Interleukin-1β and Tumor Necrosis Factor- Stimulate DNA Binding of Hypoxia-Inducible Factor-1

Thomas Hellwig‐Bürgel, Karen Rutkowski, Eric Metzen et al. · Blood · 1999 · 440 citations

Intracellular localisation of human HIF-1α hydroxylases:implications for oxygen sensing

Eric Metzen, Utta Berchner‐Pfannschmidt, Petra Stengel et al. · Journal of Cell Science · 2003 · 428 citations

Intracellular Localisation, Reductive Stress, Transcriptional Regulation +15

Nitric Oxide Impairs Normoxic Degradation of HIF-1α by Inhibition of Prolyl Hydroxylases

Eric Metzen, Jie Zhou, Wolfgang Jelkmann et al. · Molecular Biology of the Cell · 2003 · 403 citations · Full text

Nitric Oxide, Redox Biology, Oxidative Stress +20

Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-α-prolyl-4-hydroxylases

Jan H. Marxsen, Petra Stengel, Kathrin Doege et al. · Biochemical Journal · 2004 · 384 citations · Full text