Luke J. O’Connor

Distinguishing genetic correlation from causation across 52 diseases and complex traits

Luke J. O’Connor, Alkes L. Price · Nature Genetics · 2018 · 428 citations · Full text

Disease Susceptibility, Complex Trait Genetics, Genotype-phenotype Association +13

Functionally informed fine-mapping and polygenic localization of complex trait heritability

Omer Weissbrod, Farhad Hormozdiari, Christian Benner et al. · Nature Genetics · 2020 · 373 citations · Full text

Genetic Analysis, Developmental Biology, Quantitative Genetics +10

Shared genetic and experimental links between obesity-related traits and asthma subtypes in UK Biobank

Zhaozhong Zhu, Yanjun Guo, Huwenbo Shi et al. · Journal of Allergy and Clinical Immunology · 2019 · 370 citations · Full text

Obesity, Metabolic Syndrome, Asthma +12

Quantifying genetic effects on disease mediated by assayed gene expression levels

Douglas Yao, Luke J. O’Connor, Alkes L. Price et al. · Nature Genetics · 2020 · 329 citations · Full text

Genetic Effects, Genetic Analysis, Disease Susceptibility +10

Extreme Polygenicity of Complex Traits Is Explained by Negative Selection

Luke J. O’Connor, Armin Schoech, Farhad Hormozdiari et al. · The American Journal of Human Genetics · 2019 · 290 citations · Full text

Biology, Genotype-phenotype Association, Medicine +10