D O Wirak

Deposits of Amyloid β Protein in the Central Nervous System of Transgenic Mice

D O Wirak, Richard M. Bayney, T V Ramabhadran et al. · Science · 1991 · 140 citations

Microinjecting DNA into mouse ova to study DNA replication and gene expression and to produce transgenic animals.

Melvin L. DePamphilis, Sofie Herman, Encarnación Martı́nez-Salas et al. · PubMed · 1990 · 74 citations

Transgenic Mouse Models, Medicine, Genetics +13

Regulatory region of human amyloid precursor protein (APP) gene promotes neuron-specific gene expression in the CNS of transgenic mice.

D O Wirak, Richard M. Bayney, Christof Kundel et al. · The EMBO Journal · 1991 · 69 citations · Full text

Neurodegenerative Diseases, Molecular Neuroscience, Neurobiology Of Disease +11

Processing of the Pre‐β‐amyloid Protein by Cathepsin <scp>d</scp> is Enhanced by a Familial Alzheimer's Disease Mutation

Robert N. Dreyer, Kathryn M. Bausch, Paul Fracasso et al. · European Journal of Biochemistry · 1994 · 65 citations · Full text

-Amide Cleavage, Molecular Biology, Alzheimer's Disease +17

In the absence of a downstream element, the apolipoprotein E gene is expressed at high levels in kidneys of transgenic mice.

W. Scott Simonet, Nathan Bucay, S J Lauer et al. · Journal of Biological Chemistry · 1990 · 60 citations · Full text

Genetics, Renal Pathology, Molecular Genetics +17