LINE-1 activation after fertilization regulates global chromatin accessibility in the early mouse embryo

Joanna W. Jachowicz, Xinyang Bing, Julien Pontabry, +3

Nature Genetics

ChromatinEmbryologyDevelopmental BiologyChromatin StructureLine-1 Activation +11

RNA promotes the formation of spatial compartments in the nucleus

Sofia A. Quinodoz, Joanna W. Jachowicz, Prashant Bhat, +10

Cell

Developmental BiologyRna BiologySpatial CompartmentsMorphogenesisGene Expression +4

Single-cell measurement of higher-order 3D genome organization with scSPRITE

Mary V. Arrastia, Joanna W. Jachowicz, Noah Ollikainen, +6

Nature Biotechnology

ChromatinPattern FormationCell DivisionSingle Cell SequencingMedicine +7

Xist nucleates local protein gradients to propagate silencing across the X chromosome

Yolanda Markaki, Johnny Gan Chong, Yuying Wang, +15

Cell

ChromatinTranscriptional RegulationChromatin StructureX ChromosomeGenetics +9

Xist spatially amplifies SHARP/SPEN recruitment to balance chromosome-wide silencing and specificity to the X chromosome

Joanna W. Jachowicz, Mackenzie Strehle, Abhik K. Banerjee, +3

Nature Structural & Molecular Biology

ChromatinSharp/spen RecruitmentX ChromosomeGeneticsChromosome-wide Silencing +8

RNA promotes the formation of spatial compartments in the nucleus

Sofia A. Quinodoz, Prashant Bhat, Noah Ollikainen, +8

Nuclear StructureGeneticsRna SplicingMolecular BiologyEpigenetics +22

Heterochromatin establishment at pericentromeres depends on nuclear position

Joanna W. Jachowicz, Angèle Santenard, Ambre Bender, +2

Genes & Development

Nuclear StructureEpigenetic ChangeGeneticsMolecular BiologyReproductive Biology +18

Simultaneous mapping of 3D structure and nascent RNAs argues against nuclear compartments that preclude transcription

Isabel N. Goronzy, Sofia A. Quinodoz, Joanna W. Jachowicz, +3

Cell Reports

A single-cell method to map higher-order 3D genome organization in thousands of individual cells reveals structural heterogeneity in mouse ES cells

Mary V. Arrastia, Joanna W. Jachowicz, Noah Ollikainen, +6

Nuclear StructureGeneticsSingle-cell MethodDna AnalysisMolecular Biology +24

Deletion of LBR N-terminal domains recapitulates Pelger-Huet anomaly phenotypes in mouse without disrupting X chromosome inactivation

Alexander N. Young, Emerald Perlas, Nerea Ruiz-Blanes, +6

Communications Biology