Manuela Sum

KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells

Eric Metzger, Sheng Wang, Sylvia Urban et al. · Nature Structural & Molecular Biology · 2019 · 109 citations

Life Sciences, Cancer Biology, Molecular Biology +12

Development of a NanoBRET assay to validate inhibitors of Sirt2-mediated lysine deacetylation and defatty-acylation that block prostate cancer cell migration

Anja Vogelmann, Matthias Schiedel, Nathalie Wössner et al. · RSC Chemical Biology · 2022 · 28 citations · Full text

Medicine, Molecular Biology, Oncology +13

The histone code reader Spin1 controls skeletal muscle development

Holger Greschik, Delphine Duteil, Nadia Messaddeq et al. · Cell Death and Disease · 2017 · 18 citations · Full text

Life Sciences, Developmental Biology, Genetics +17

Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity

Sheng Wang, Sebastian O. Klein, Sylvia Urban et al. · Nature Communications · 2024 · 17 citations · Full text

Medicine, Oncology, Pharmacology +12

Structure–Activity Studies of 1,2,4-Oxadiazoles for the Inhibition of the NAD⁺-Dependent Lysine Deacylase Sirtuin 2

Arianna Colcerasa, Florian Friedrich, Jelena Melesina et al. · Journal of Medicinal Chemistry · 2024 · 12 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15