Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization

Anwari Akhter, Kyle Caution, Arwa Abu Khweek, +10

Immunity

Protein FunctionVirulence FactorPathogenesisImmunologyCytoskeleton +8

Aging is associated with hypermethylation of autophagy genes in macrophages

Hany Khalil, Mia Tazi, Kyle Caution, +7

Epigenetics

MitophagyAgingEpigenetic ChangeDna MethylationImmunology +18

Hypoxia induces chemoresistance in ovarian cancer cells by activation of signal transducer and activator of transcription 3

Karuppaiyah Selvendiran, Anna Bratasz, M. Lakshmi Kuppusamy, +3

International Journal of Cancer

Cancer BiologyRedox BiologyTumor BiologyOxidative StressOvarian Cancer +18

Streptococcus pneumoniae Can Utilize Multiple Sources of Hyaluronic Acid for Growth

Carolyn Marion, Jason M. Stewart, Mia Tazi, +4

Infection and Immunity

IFN-γ Stimulates Autophagy-Mediated Clearance of Burkholderia cenocepacia in Human Cystic Fibrosis Macrophages

Kaivon Assani, Mia Tazi, Amal O. Amer, +1

PLoS ONE

Inflammatory Lung DiseaseMicrobial PathogensInnate Immune SystemImmunologyImmune Regulation +19

Safe and targeted anticancer efficacy of a novel class of antioxidant-conjugated difluorodiarylidenyl piperidones: Differential cytotoxicity in healthy and cancer cells

Karuppaiyah Selvendiran, Shabnam Ahmed, Alex Dayton, +7

Free Radical Biology and Medicine

Medicinal ChemistryDrug TargetingMedicineTargeted Anticancer EfficacyNovel Class +7

Elevated <i>Mirc1/Mir17-92</i> cluster expression negatively regulates autophagy and CFTR (cystic fibrosis transmembrane conductance regulator) function in CF macrophages

Mia Tazi, Duaa Dakhlallah, Kyle Caution, +12

Autophagy

Inflammatory Lung DiseaseImmunologyCellular PhysiologyInflammationCell Autophagy +14

Depletion of the Ubiquitin-binding Adaptor Molecule SQSTM1/p62 from Macrophages Harboring cftr ΔF508 Mutation Improves the Delivery of Burkholderia cenocepacia to the Autophagic Machinery

Basant Abdulrahman, Arwa Abu Khweek, Anwari Akhter, +10

Journal of Biological Chemistry

A bacterial protein promotes the recognition of the <i>L</i><i>egionella pneumophila</i> vacuole by autophagy

Arwa Abu Khweek, Kyle Caution, Anwari Akhter, +9

European Journal of Immunology

MitophagyLegionella PneumophilaImmunologyCell DeathBacterial Pathogens +15

Exaggerated inflammatory responses mediated by Burkholderia cenocepacia in human macrophages derived from Cystic fibrosis patients

Benjamin T. Kopp, Basant Abdulrahman, Arwa Abu Khweek, +7

Biochemical and Biophysical Research Communications

InflammationAnti-inflammatoryInflammatory Lung DiseaseLung InflammationHuman Macrophages +9