Matej Janežič

4,6-Substituted-1,3,5-triazin-2(1H)-ones as monocyclic catalytic inhibitors of human DNA topoisomerase IIα targeting the ATP binding site

Barbara Pogorelčnik, Matej Janežič, Izidor Sosič et al. · Bioorganic & Medicinal Chemistry · 2015 · 35 citations · Full text

Molecular Pharmacology, Biochemistry, Natural Sciences +8

Substituted 4,5′-Bithiazoles as Catalytic Inhibitors of Human DNA Topoisomerase IIα

Kaja Bergant Loboda, Matej Janežič, Martina Štampar et al. · Journal of Chemical Information and Modeling · 2020 · 33 citations · Full text

Structure-guided optimization of 4,6-substituted-1,3,5-triazin-2(1H)-ones as catalytic inhibitors of human DNA topoisomerase IIα

Kaja Bergant, Matej Janežič, Katja Valjavec et al. · European Journal of Medicinal Chemistry · 2019 · 26 citations · Full text

Medicinal Chemistry, Biochemistry, Natural Sciences +7

Dynophore-Based Approach in Virtual Screening: A Case of Human DNA Topoisomerase IIα

Matej Janežič, Katja Valjavec, Kaja Bergant Loboda et al. · International Journal of Molecular Sciences · 2021 · 21 citations · Full text

Drug Target, Dna Analysis, Molecular Biology +28

Catalytic Mechanism of ATP Hydrolysis in the ATPase Domain of Human DNA Topoisomerase IIα

Mitja Ogrizek, Matej Janežič, Katja Valjavec et al. · Journal of Chemical Information and Modeling · 2022 · 18 citations · Full text

Atpase Domain, Engineering, Molecular Biology +18