Alejandro J. Da Silva Sanchez

Nanoparticles Containing Oxidized Cholesterol Deliver mRNA to the Liver Microenvironment at Clinically Relevant Doses

Kalina Paunovska, Alejandro J. Da Silva Sanchez, Cory D. Sago et al. · Advanced Materials · 2019 · 186 citations · Full text

Nanoparticle single-cell multiomic readouts reveal that cell heterogeneity influences lipid nanoparticle-mediated messenger RNA delivery

Curtis Dobrowolski, Kalina Paunovska, Elisa Schrader Echeverri et al. · Nature Nanotechnology · 2022 · 87 citations · Full text

Cell Heterogeneity, Medicine, Single-cell Genomics +5

The Transcriptional Response to Lung-Targeting Lipid Nanoparticles <i>in Vivo</i>

Afsane Radmand, Melissa P. Lokugamage, Hyejin Kim et al. · Nano Letters · 2023 · 62 citations · Full text

High-throughput screens identify a lipid nanoparticle that preferentially delivers mRNA to human tumors in vivo

Sebastian G. Huayamares, Melissa P. Lokugamage, Regina Rab et al. · Journal of Controlled Release · 2023 · 60 citations · Full text

Human Tumors, Tumor Biology, Nanomedicine +9

Nanoparticle stereochemistry-dependent endocytic processing improves in vivo mRNA delivery

Marine Z. C. Hatit, Curtis Dobrowolski, Melissa P. Lokugamage et al. · Nature Chemistry · 2023 · 59 citations · Full text

Nanoparticles, Nanomedicine, Engineering +4