Jay Wrobel

Mechanism and synthetic utility of boron trifluoride etherate-promoted organolithium additions

Michael J. Eis, Jay Wrobel, Bruce Ganem · Journal of the American Chemical Society · 1984 · 230 citations

Natural Sciences, Chemistry, Inorganic Chemistry +9

Design, Synthesis, and SAR of New Pyrrole-Oxindole Progesterone Receptor Modulators Leading to 5-(7-Fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1<i>H</i>-indol-5-yl)-1-methyl-1<i>H</i>-pyrrole-2-carbonitrile (WAY-255348)

Andrew Fensome, William R. Adams, Andrea L. Adams et al. · Journal of Medicinal Chemistry · 2008 · 198 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Novel spirosuccinimides with incorporated isoindolone and benzisothiazole 1,1-dioxide moieties as aldose reductase inhibitors and antihyperglycemic agents

Jay Wrobel, Arlene Dietrich, S. Woolson et al. · Journal of Medicinal Chemistry · 1992 · 191 citations

Medicine, Medicinal Chemistry, Pharmacology +6

Discovery of XL335 (WAY-362450), a Highly Potent, Selective, and Orally Active Agonist of the Farnesoid X Receptor (FXR)

Brenton Flatt, Richard Martin, Tielin Wang et al. · Journal of Medicinal Chemistry · 2009 · 161 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

PTP1B Inhibition and Antihyperglycemic Activity in the ob/ob Mouse Model of Novel 11-Arylbenzo[<i>b</i>]naphtho[2,3-<i>d</i>]furans and 11-Arylbenzo[<i>b</i>]naphtho[2,3-<i>d</i>]thiophenes

Jay Wrobel, Janet Sredy, Christopher Moxham et al. · Journal of Medicinal Chemistry · 1999 · 126 citations · Full text

Medicine, Biochemistry, Pharmacology +6