5-Hydroxymethylcytosine Plays a Critical Role in Glioblastomagenesis by Recruiting the CHTOP-Methylosome Complex

Hiroki Takai, Koji Masuda, Tomohiro Sato, +17

Cell Reports

Combining Machine Learning and Pharmacophore-Based Interaction Fingerprint for in Silico Screening

Tomohiro Sato, Teruki Honma, Shigeyuki Yokoyama

Journal of Chemical Information and Modeling

EngineeringMachine LearningHit IdentificationBiometricsFingerprint Analysis +20

A Rac GTPase-Activating Protein, MgcRacGAP, Is a Nuclear Localizing Signal-Containing Nuclear Chaperone in the Activation of STAT Transcription Factors

Toshiyuki Kawashima, Ying Bao, Yukinori Minoshima, +13

Molecular and Cellular Biology

Signal RecognitionMolecular BiologyMgcracgap Binding SiteSignal-containing Nuclear ChaperoneTranscriptional Regulation +14

Support Vector Machine model for hERG inhibitory activities based on the integrated hERG database using descriptor selection by NSGA-II

Keiji Ogura, Tomohiro Sato, Hitomi Yuki, +1

Scientific Reports

FMODB: The World’s First Database of Quantum Mechanical Calculations for Biomacromolecules Based on the Fragment Molecular Orbital Method

Daisuke Takaya, Chiduru Watanabe, Shunpei Nagase, +15

Journal of Chemical Information and Modeling

Fragment Molecular OrbitalEngineeringMolecular BiologyComputational ChemistryMolecular Computing +23

Construction of an integrated database for hERG blocking small molecules

Tomohiro Sato, Hitomi Yuki, Keiji Ogura, +1

PLoS ONE

Drug TargetSar DatabaseMolecular BiologyChemical BiologyMolecular Computing +19

Presence of immunoreactive salusin-β in human plasma and urine

Kengo Sato, Tomohiro Sato, Teruo Susumu, +2

Regulatory Peptides

UrologyRenal FunctionRenal PathologyHuman PlasmaRenal Pathophysiology +3

Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase of <i>Trypanosoma brucei brucei</i>

E.O. Balogun, D.K. Inaoka, T. Shiba, +15

The FASEB Journal

Application of Support Vector Machine to Three-Dimensional Shape-Based Virtual Screening Using Comprehensive Three-Dimensional Molecular Shape Overlay with Known Inhibitors

Tomohiro Sato, Hitomi Yuki, Daisuke Takaya, +3

Journal of Chemical Information and Modeling

EngineeringMachine LearningHit IdentificationKnown InhibitorsBiomedical Engineering +19

Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents

Yosuke Nishigaya, Shohei Takase, Tatsunobu Sumiya, +15

Journal of Medicinal Chemistry