SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer

Yibo Xue, Brian Meehan, Zheng Qing Fu, +24

Nature Communications

CD44 Promotes PD-L1 Expression and Its Tumor-Intrinsic Function in Breast and Lung Cancers

Tim Kong, Ryuhjin Ahn, Kangning Yang, +15

Cancer Research

CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary

Yibo Xue, Brian Meehan, Elizabeth A. Macdonald, +32

Nature Communications

Pacritinib is a potent ACVR1 inhibitor with significant anemia benefit in patients with myelofibrosis

Stephen T. Oh, Ruben A. Mesa, Claire Harrison, +15

Blood Advances

Antifibrotic TherapyImmunologyCardiovascular PharmacologyPharmacotherapyInflammation +15

Direct Binding between Pre-S1 and TRP-like Domains in TRPP Channels Mediates Gating and Functional Regulation by PIP2

Wang Zheng, Ruiqi Cai, Laura Hofmann, +13

Cell Reports

eIF4A Inhibitors Suppress Cell-Cycle Feedback Response and Acquired Resistance to CDK4/6 Inhibition in Cancer

Tim Kong, Yibo Xue, Regina Cencic, +11

Molecular Cancer Therapeutics

Identification and characterization of hydrophobic gate residues in TRP channels

Wang Zheng, Ruikun Hu, Ruiqi Cai, +10

The FASEB Journal

DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression

Tim Kong, Angelo B. A. Laranjeira, Kangning Yang, +12

Nature Cancer

Signal TransductionSignaling PathwayReceptor Tyrosine KinaseImmunologyCell Death +5

Multiomic profiling reveals metabolic alterations mediating aberrant platelet activity and inflammation in myeloproliferative neoplasms

Fan He, Angelo B. A. Laranjeira, Tim Kong, +15

Journal of Clinical Investigation

EngineeringImmunologyMyeloproliferative NeoplasmsPlatelet PathobiologyMultiomics +23

Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer

Xianbing Zhu, Zheng Fu, Kendall Dutchak, +22

Cancer Research