Claudine Amar

Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug.

Philippe Beaune, Patrick M. Dansette, Daniel Mansuy et al. · Proceedings of the National Academy of Sciences · 1987 · 324 citations · Full text

Life Sciences, Biochemistry, Immunology +17

Thiophene S-oxides as new reactive metabolites: formation by cytochrome P-450 dependent oxidation and reaction with nucleophiles

Daniel Mansuy, Philippe Valadon, Irène Erdelmeier et al. · Journal of the American Chemical Society · 1991 · 93 citations

Life Sciences, Biochemistry, Chemistry +16

Human‐liver cytochromes <i>P</i>‐450 expressed in yeast as tools for reactive‐metabolite formation studies

Marcel Garcia, Patrick M. Dansette, Philippe Valadon et al. · European Journal of Biochemistry · 1993 · 90 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Thiophene Sulfoxides as Reactive Metabolites:  Formation upon Microsomal Oxidation of a 3-Aroylthiophene and Fate in the Presence of Nucleophiles<i>in Vitro</i>and<i>in Vivo</i>

Philippe Valadon, Patrick M. Dansette, Jean‐Pierre Girault et al. · Chemical Research in Toxicology · 1996 · 88 citations

Life Sciences, Biochemistry, Chemistry +15

Hydroxylation and formation of electrophilic metabolites of tienilic acid and its isomer by human liver microsomes

Patrick M. Dansette, Claudine Amar, Philippe Valadon et al. · Biochemical Pharmacology · 1991 · 71 citations

Medicine, Biochemistry, Pharmacology +9