Darren Cawkill

Cloning and Characterization of the Human and Mouse PDE7B, a Novel cAMP-Specific Cyclic Nucleotide Phosphodiesterase

Clare Gardner, Nicola Robas, Darren Cawkill et al. · Biochemical and Biophysical Research Communications · 2000 · 95 citations

Molecular Pharmacology, Protein Function, Molecular Physiology +9

Biased ligand quantification in drug discovery: from theory to high throughput screening to identify new biased μ opioid receptor agonists

David Winpenny, Mellissa Clark, Darren Cawkill · British Journal of Pharmacology · 2016 · 61 citations · Full text

Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response

Besma Benredjem, Jonathan Gallion, Dennis Pelletier et al. · Nature Communications · 2019 · 42 citations · Full text

Engineering, Translational Bioinformatics, Medicine +9

Plate-Based Phenotypic Screening for Pain Using Human iPSC-Derived Sensory Neurons

Peter Stacey, Anne Mai Wassermann, Laura R Kammonen et al. · SLAS DISCOVERY · 2018 · 32 citations · Full text

Preclinical trial of a MAP4K4 inhibitor to reduce infarct size in the pig: does cardioprotection in human stem cell-derived myocytes predict success in large mammals?

Maaike te Lintel Hekkert, Gary Newton, Kathryn Chapman et al. · Basic Research in Cardiology · 2021 · 27 citations · Full text