Gary Newton

MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo

Lorna R. Fiedler, Kathryn Chapman, Min Xie et al. · Cell stem cell · 2019 · 110 citations · Full text

Life Sciences, Cardiology, Cell Biology +14

Highly diastereoselective 1,3-dipolar cycloaddition reactions of trans-2-methylene-1,3-dithiolane 1,3-dioxide with 3-oxidopyridinium and 3-oxidopyrylium betaines: a route to the tropane skeleton

Varinder K. Aggarwal, Richard S. Grainger, Gary Newton et al. · Organic & Biomolecular Chemistry · 2003 · 44 citations

Natural Sciences, Chemistry, Medicinal Chemistry +12

Selective protection of human cardiomyocytes from anthracycline cardiotoxicity by small molecule inhibitors of MAP4K4

Pelin Golforoush, Priyanka Narasimhan, Patricia Cháves et al. · Scientific Reports · 2020 · 34 citations · Full text

Medicine, Cardiology, Pharmacology +15

The Discovery of Potent, Selective, and Reversible Inhibitors of the House Dust Mite Peptidase Allergen Der p 1: An Innovative Approach to the Treatment of Allergic Asthma

Gary Newton, Trevor R. Perrior, Kerry Jenkins et al. · Journal of Medicinal Chemistry · 2014 · 29 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Preclinical trial of a MAP4K4 inhibitor to reduce infarct size in the pig: does cardioprotection in human stem cell-derived myocytes predict success in large mammals?

Maaike te Lintel Hekkert, Gary Newton, Kathryn Chapman et al. · Basic Research in Cardiology · 2021 · 27 citations · Full text

Medicine, Cardiology, Pharmacology +16