James T. Loch

The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective α7 nicotinic receptor partial agonist

John E. Macor, David Gurley, Thomas H. Lanthorn et al. · Bioorganic & Medicinal Chemistry Letters · 2001 · 159 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +15

Pyrrolamide DNA Gyrase Inhibitors: Fragment-Based Nuclear Magnetic Resonance Screening To Identify Antibacterial Agents

Ann E. Eakin, Oluyinka Green, Neil J. Hales et al. · Antimicrobial Agents and Chemotherapy · 2011 · 134 citations

Pharmacy, Medicinal Chemistry, Molecular Biology +17

(−)-Spiro[1-azabicyclo[2.2.2]octane-3,5‘-oxazolidin-2‘-one], a Conformationally Restricted Analogue of Acetylcholine, Is a Highly Selective Full Agonist at the α7 Nicotinic Acetylcholine Receptor

G. B. MULLEN, James Napier, Michael Balestra et al. · Journal of Medicinal Chemistry · 2000 · 132 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Pyrrolamide DNA gyrase inhibitors: Optimization of antibacterial activity and efficacy

Brian Sherer, Kenneth G. Hull, Oluyinka Green et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 121 citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Biology +14

Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase: Structure–Activity Relationships and Chiral Preference of a New Hydrophobic Binding Region

Sameer Kawatkar, Thomas A. Keating, N.B. Olivier et al. · Journal of Medicinal Chemistry · 2014 · 63 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15