James T. Loch

The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective α7 nicotinic receptor partial agonist

John E. Macor, David Gurley, Thomas H. Lanthorn et al. · Bioorganic & Medicinal Chemistry Letters · 2001 · 157 citations · Full text

Pyrrolamide DNA Gyrase Inhibitors: Fragment-Based Nuclear Magnetic Resonance Screening To Identify Antibacterial Agents

Ann E. Eakin, Oluyinka Green, Neil J. Hales et al. · Antimicrobial Agents and Chemotherapy · 2011 · 132 citations

Essential Enzyme, Lead Identification, Antimicrobial Chemotherapy +18

(−)-Spiro[1-azabicyclo[2.2.2]octane-3,5‘-oxazolidin-2‘-one], a Conformationally Restricted Analogue of Acetylcholine, Is a Highly Selective Full Agonist at the α7 Nicotinic Acetylcholine Receptor

G. B. MULLEN, James Napier, Michael Balestra et al. · Journal of Medicinal Chemistry · 2000 · 132 citations · Full text

Pharmacotherapy, Social Sciences, Molecular Pharmacology +19

Pyrrolamide DNA gyrase inhibitors: Optimization of antibacterial activity and efficacy

Brian Sherer, Kenneth G. Hull, Oluyinka Green et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 119 citations · Full text

Inhibitory Activity, Medicinal Chemistry, Medicine +10

Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase: Structure–Activity Relationships and Chiral Preference of a New Hydrophobic Binding Region

Sameer Kawatkar, Thomas A. Keating, N.B. Olivier et al. · Journal of Medicinal Chemistry · 2014 · 61 citations

Antibiotic Adjuvant, Molecular Biology, Peptide Science +23