Crystal Structure of Arrestin-3 Reveals the Basis of the Difference in Receptor Binding Between Two Non-visual Subtypes

Xuanzhi Zhan, Luis E. Gimenez, Vsevolod V. Gurevich, +1

Journal of Molecular Biology

Crystal StructureSignal TransductionMolecular PhysiologyG Protein-coupled ReceptorNon-visual Subtypes +7

A Superfamily of Voltage-gated Sodium Channels in Bacteria

Ryuta Koishi, Haoxing Xu, Dejian Ren, +4

Journal of Biological Chemistry

Crystal structure of Clostridium difficile toxin A

Nicole M. Chumbler, Stacey A. Rutherford, Zhifen Zhang, +7

Nature Microbiology

Microbial ToxinCrystal StructureToxinologyProtein X-ray CrystallographyMolecular Biology +4

A Single Mutation in Arrestin-2 Prevents ERK1/2 Activation by Reducing c-Raf1 Binding

Sergio Coffa, Maya Breitman, Benjamin W. Spiller, +1

Biochemistry

Molecular RegulationMolecular BiologyArg307ala MutationMolecular PharmacologySignaling Pathway +16

Alpha4 Is a Ubiquitin-Binding Protein That Regulates Protein Serine/Threonine Phosphatase 2A Ubiquitination

Jamie L. McConnell, Guy R. Watkins, Sarah E. Soss, +5

Biochemistry

Pp2ac PolyubiquitinationSystems BiologySignal TransductionProtein FunctionBiochemistry +12

A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells

Heather K. Kroh, Ramyavardhanee Chandrasekaran, Zhifen Zhang, +9

Journal of Biological Chemistry

Microbial ToxinNeutralizing AntibodyEnzymatic CargoToxinologyPathogenesis +8

Human Rotavirus VP6-Specific Antibodies Mediate Intracellular Neutralization by Binding to a Quaternary Structure in the Transcriptional Pore

Mohammed S. Aiyegbo, Gopal Sapparapu, Benjamin W. Spiller, +11

PLoS ONE

Monoubiquitination Promotes Calpain Cleavage of the Protein Phosphatase 2A (PP2A) Regulatory Subunit α4, Altering PP2A Stability and Microtubule-associated Protein Phosphorylation

Guy R. Watkins, Ning Wang, Matthew D. Mazalouskas, +6

Journal of Biological Chemistry

Transcriptional RegulationSystems BiologySignal TransductionCalpain CleavageAltering Pp2a Stability +13

The E3 Ubiquitin Ligase- and Protein Phosphatase 2A (PP2A)-binding Domains of the Alpha4 Protein Are Both Required for Alpha4 to Inhibit PP2A Degradation

Michele L. Lenoue-Newton, Guy R. Watkins, Ping Zou, +4

Journal of Biological Chemistry

The Chlamydia Effector Chlamydial Outer Protein N (CopN) Sequesters Tubulin and Prevents Microtubule Assembly

Tara L. Archuleta, Yaqing Du, Chauca A. English, +5

Journal of Biological Chemistry

Sequesters TubulinChlamydia SpeciesProtein SecretionProtein FunctionCell Division +12