Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3 inflammasome

Laura R. Hoyt, Matthew J. Randall, Jennifer L. Ather, +8

Redox Biology

Ziritaxestat, a Novel Autotaxin Inhibitor, and Lung Function in Idiopathic Pulmonary Fibrosis

Toby M. Maher, Paul Ford, Kevin M. Brown, +24

JAMA

IL-1/inhibitory κB kinase ε–induced glycolysis augment epithelial effector function and promote allergic airways disease

Xi Qian, Reem Aboushousha, Cheryl van de Wetering, +26

Journal of Allergy and Clinical Immunology

InflammationCytokineAllergyInflammatory Lung DiseaseLung Inflammation +11

Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation

Laura R. Hoyt, Jennifer L. Ather, Matthew J. Randall, +5

The Journal of Immunology

Restored Tyrosine PhosphorylationImmunologyImmune RegulationPathologyCell Death +23

The Tobacco Smoke Component, Acrolein, Suppresses Innate Macrophage Responses by Direct Alkylation of c-Jun N-Terminal Kinase

Milena Hristova, Page C. Spiess, David I. Kasahara, +3

American Journal of Respiratory Cell and Molecular Biology

Acute Lung InjuryInflammatory Lung DiseaseLung InflammationInnate Immune SystemImmunology +29

Weight Loss Decreases Inherent and Allergic Methacholine Hyperresponsiveness in Mouse Models of Diet-Induced Obese Asthma

Jennifer L. Ather, Michael H. Chung, Laura R. Hoyt, +11

American Journal of Respiratory Cell and Molecular Biology

AsthmaObese AsthmaEnvironmental AllergyImmunologyAllergen +17

Adaptation to acrolein through upregulating the protection by glutathione in human bronchial epithelial cells: The materialization of the hormesis concept

Mireille M.J.P.E. Sthijns, Matthew J. Randall, Aalt Bast, +1

Biochemical and Biophysical Research Communications

AsthmaRespiratory ToxicologyHormesis ConceptMedicineLipid Peroxidation +5

Protein alkylation by the α,β‐unsaturated aldehyde acrolein. A reversible mechanism of electrophile signaling?

Matthew J. Randall, Milena Hristova, Albert van der Vliet

FEBS Letters

Acrolein-induced activation of mitogen-activated protein kinase signaling is mediated by alkylation of thioredoxin reductase and thioredoxin 1

Matthew J. Randall, Page C. Spiess, Milena Hristova, +2

Redox Biology

Acrolein exposure suppresses antigen-induced pulmonary inflammation

Page C. Spiess, David I. Kasahara, Aida Habibovic, +4

Respiratory Research