Dysregulated Class I histone deacetylases are indicators of poor prognosis in multiple myeloma

Sridurga Mithraprabhu, Anna Kalff, Annie Chow, +2

Epigenetics

Hematological MalignancyTumor BiologyChromatinClass IiHistone Deacetylases +12

Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition

Simon J. Hogg, Olga Motorna, Leonie A. Cluse, +39

Molecular Cell

Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1

Jia-Nan Gong, Tiffany Khong, David Segal, +9

Blood

Circulating tumour DNA analysis demonstrates spatial mutational heterogeneity that coincides with disease relapse in myeloma

Sridurga Mithraprabhu, Tiffany Khong, Malarmathy Ramachandran, +11

Leukemia

Hematological MalignancyDisease RelapseOncologySomatic VariantTumor Heterogeneity +10

The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells

Katherine Monaghan, Tiffany Khong, Christopher J. Burns, +1

Leukemia

Hematological MalignancyTumor BiologyPrevents ProliferationInduces ApoptosisApoptosis +9

Targeting HSP 90 Induces Apoptosis and Inhibits Critical Survival and Proliferation Pathways in Multiple Myeloma

Tiffany Khong, Andrew Spencer

Molecular Cancer Therapeutics

Client ProteinsHsp ExpressionImmunologyCell DeathMyeloid Neoplasia +18

Monitoring tumour burden and therapeutic response through analysis of circulating tumour DNA and extracellular RNA in multiple myeloma patients

Sridurga Mithraprabhu, Rachel Morley, Tiffany Khong, +10

Leukemia

Hematological MalignancyOncologyTumour DnaHealth SciencesNucleic Acid Biomarkers +12

β-Catenin Inhibitor BC2059 Is Efficacious as Monotherapy or in Combination with Proteasome Inhibitor Bortezomib in Multiple Myeloma

Ioanna Savvidou, Tiffany Khong, Andrew Cuddihy, +3

Molecular Cancer Therapeutics

The effect of azacitidine on interleukin-6 signaling and nuclear factor- B activation and its in vitro and in vivo activity against multiple myeloma

Tiffany Khong, John Sharkey, Adam Spencer

Haematologica

Circulating Tumour DNA Analysis for Tumour Genome Characterisation and Monitoring Disease Burden in Extramedullary Multiple Myeloma

Sridurga Mithraprabhu, Shreerang Sirdesai, Maoshan Chen, +2

International Journal of Molecular Sciences

Mixed-phenotype Acute LeukemiaImmunologyMonitoring Disease BurdenPathologyTumor Biology +18