Ho Yin Lo

Substituted pyrazoles as novel sEH antagonist: Investigation of key binding interactions within the catalytic domain

Ho Yin Lo, Chuk C. Man, Roman Fleck et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 41 citations · Full text

Combinatorial Chemistry, Substituted Pyrazoles, Catalytic Domain +7

Synthesis, SAR, and Series Evolution of Novel Oxadiazole-Containing 5-Lipoxygenase Activating Protein Inhibitors: Discovery of 2-[4-(3-{(<i>R</i>)-1-[4-(2-Amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-<i>N</i>,<i>N</i>-dimethyl-acetamide (BI 665915)

Hidenori Takahashi, Doris Riether, Alessandra Bartolozzi et al. · Journal of Medicinal Chemistry · 2015 · 35 citations · Full text

Drug Target, Pharmacotherapy, Pharmaceutical Chemistry +19

Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk)

K.J.M. Moriarty, Hidenori Takahashi, Steven S. Pullen et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 32 citations · Full text

Medicinal Chemistry, Drug Target, Biochemistry +12

2-Aminobenzimidazoles as potent ITK antagonists: trans-stilbene-like moieties targeting the kinase specificity pocket

Ho Yin Lo, Jörg Bentzien, Roman Fleck et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 22 citations · Full text

Medicinal Chemistry, Drug Target, Biochemistry +12

Benzimidazolone as potent chymase inhibitor: Modulation of reactive metabolite formation in the hydrophobic (P1) region

Ho Yin Lo, Peter Nemoto, Jin‐Man Kim et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 20 citations · Full text

Medicinal Chemistry, Potent Chymase Inhibitor, Pharmaceutical Science +10