Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

Konstantinos J. Mavrakis, E. Robert McDonald, Michael R. Schlabach, +41

Science

Molecular Architecture of Quartet MOZ/MORF Histone Acetyltransferase Complexes

Mukta Ullah, Nadine Pelletier, Lin Xiao, +10

Molecular and Cellular Biology

Molecular RegulationMolecular BiologyComplex FormationEpigeneticsTranscriptional Regulation +16

RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across <i>FGFR2</i> Alterations and Resistance Mutations

Vivek Subbiah, Vaibhav Sahai, Dejan Maglic, +28

Cancer Discovery

The Tumor Suppressor Kinase LKB1 Activates the Downstream Kinases SIK2 and SIK3 to Stimulate Nuclear Export of Class IIa Histone Deacetylases

Donald R. Walkinshaw, Ryan Weist, Go-Woon Kim, +7

Journal of Biological Chemistry

Proteases and sFlt-1 Release in the Human Placenta

Songping Zhao, Yang Gu, Ruping Fan, +3

Placenta

Human PlacentaPlacental DevelopmentMedicineGynecologyMaternal Health +3

Altered Interleukin-6 Receptor, IL-6R and gp130, Production and Expression and Decreased SOCS-3 Expression in Placentas from Women with Pre-eclampsia

Songping Zhao, Yang Gu, Qiaoxiang Dong, +2

Placenta

Socs-3 ExpressionAltered Interleukin-6 ReceptorPlacental DevelopmentImmunologyReproductive Health +10

Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2

Heike Schönherr, Pelin Ayaz, Alexander M. Taylor, +26

Proceedings of the National Academy of Sciences

Combined X-ray, NMR, and Kinetic Analyses Reveal Uncommon Binding Characteristics of the Hepatitis C Virus NS3-NS4A Protease Inhibitor BI 201335

Christopher T. Lemke, Nathalie Goudreau, Songping Zhao, +4

Journal of Biological Chemistry

Virus StructureBiochemistryProtein FoldingViral HepatitisNatural Sciences +8

<i>In Vitro</i> Resistance Profile of the Hepatitis C Virus NS3 Protease Inhibitor BI 201335

Lisette Lagacé, Peter W. White, Christiane Bousquet, +11

Antimicrobial Agents and Chemotherapy

GeneticsMolecular BiologyMolecular GeneticsGenomicsAntiviral Drug +18

Use of the Fused NS4A Peptide−NS3 Protease Domain To Study the Importance of the Helicase Domain for Protease Inhibitor Binding to Hepatitis C Virus NS3-NS4A

Diane Thibeault, Marie-Josée Massariol, Songping Zhao, +5

Biochemistry

Protein AssemblyNs3 ProteinProtease Inhibitor BindingMolecular BiologyAnalytical Ultracentrifugation +19