TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways

Shoutang Wang, Raki Sudan, Vincent Peng, +20

Cell

Inflammation-Independent PathwaysNeurodegenerative DiseasesMedicineMicroglia Response +7

Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid

Antoine Drieu, Siling Du, Steffen E. Storck, +13

Nature

Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels

Jose A. Mazzitelli, Leon Smyth, Kevin A. Cross, +7

Nature Neuroscience

EpendymaNeurophysiologyNeuroanatomyCerebrospinal FluidNeural Stem Cell +9

Identification of direct connections between the dura and the brain

Leon Smyth, Di Xu, Serhat V. Okar, +19

Nature

Cognitive ScienceBrain StructureNeurophysiologyNeuroanatomyBrain Mechanism +9

Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice

Tian Zhou, Yuxin Li, Xiaoyu Li, +20

Nature Communications

NeuroD1 induces microglial apoptosis and cannot induce microglia-to-neuron cross-lineage reprogramming

Yanxia Rao, Siling Du, Baozhi Yang, +11

Neuron

GliomaMedicineCell DeathBrain-immune InteractionNeuroprotection +7

Age-related alterations in meningeal immunity drive impaired CNS lymphatic drainage

Justin Rustenhoven, Georgios Pavlou, Steffen E. Storck, +8

The Journal of Experimental Medicine

A Cre-deleter specific for embryo-derived brain macrophages reveals distinct features of microglia and border macrophages

Simone Brioschi, Julia A. Belk, Vincent Peng, +16

Immunity

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Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens

Patrick Fernandes Rodrigues, Shitong Wu, Tihana Tršan, +13

Cell

Engineered T cell therapy for central nervous system injury

Wenqing Gao, Min Woo Kim, Taitea Dykstra, +12

Nature

Regenerative MedicineCell TherapyNeuroregenerationMedicineImmunology +7