Plasma-activated medium triggers cell death and the presentation of immune activating danger signals in melanoma and pancreatic cancer cells

Amalia Azzariti, Rosa Maria Iacobazzi, R. Fonte, +9

Scientific Reports

Circulating extracellular vesicles expressing PD1 and PD-L1 predict response and mediate resistance to checkpoint inhibitors immunotherapy in metastatic melanoma

Simona Serratì, Michele Guida, R. Fonte, +9

Molecular Cancer

Cyclohexylpiperazine derivative PB28, a σ2 agonist and σ1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer

Amalia Azzariti, Nicola Antonio Colabufo, Francesco Berardi, +5

Molecular Cancer Therapeutics

Breast OncologyLow SigmaChemoprevention StrategyImmunologyPharmacotherapy +17

Hepatic stellate cells induce hepatocellular carcinoma cell resistance to sorafenib through the laminin‐332/α3 integrin axis recovery of focal adhesion kinase ubiquitination

Amalia Azzariti, Serena Mancarella, Letizia Porcelli, +5

Hepatology

CAFs and TGF-β Signaling Activation by Mast Cells Contribute to Resistance to Gemcitabine/Nabpaclitaxel in Pancreatic Cancer

Letizia Porcelli, Rosa Maria Iacobazzi, R. Fonte, +8

Cancers

Pancreatic CancerTgf-β Signaling ActivationMedicineImmunologyPharmacology +13

Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives

Nicola Antonio Colabufo, Francesco Berardi, Mariangela Cantore, +9

Bioorganic & Medicinal Chemistry

Medicinal ChemistryNatural SciencesOrganic ChemistryTetrahydroisoquinoline DerivativesChemistry +2

Gene Expression Comparison between the Lymph Node-Positive and -Negative Reveals a Peculiar Immune Microenvironment Signature and a Theranostic Role for WNT Targeting in Pancreatic Ductal Adenocarcinoma: A Pilot Study

Antonella Argentiero, Simona De Summa, R. Fonte, +7

Cancers

Cancer ImmunosurveillancePancreatic CancerImmunologyImmunoeditingPathology +13

Targeting human liver cancer cells with lactobionic acid-G(4)-PAMAM-FITC sorafenib loaded dendrimers

Rosa Maria Iacobazzi, Letizia Porcelli, Angela Lopedota, +8

International Journal of Pharmaceutics

Tumor BiologyDrug TargetingPolymer-drug ConjugateMedicineDrug Discovery +9

Sorafenib delivery nanoplatform based on superparamagnetic iron oxide nanoparticles magnetically targets hepatocellular carcinoma

Nicoletta Depalo, Rosa Maria Iacobazzi, G. Valente, +13

Nano Research

Aurora B kinase inhibitor AZD1152: determinants of action and ability to enhance chemotherapeutics effectiveness in pancreatic and colon cancer

Amalia Azzariti, Guido Bocci, Letizia Porcelli, +10

British Journal of Cancer

Tumor BiologyOncologyPancreatic CancerGastrointestinal OncologyMedicine +7