Lucy Farrimond

Impairment of Mitochondrial Calcium Buffering Links Mutations in C9ORF72 and TARDBP in iPS-Derived Motor Neurons from Patients with ALS/FTD

Ruxandra Dafinca, Paola Barbagallo, Lucy Farrimond et al. · Stem Cell Reports · 2020 · 127 citations · Full text

Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction

David F. Gordon, Ruxandra Dafinca, Jakub Scaber et al. · Neurobiology of Disease · 2018 · 104 citations · Full text

Bac Transgenic Mice, Neurodegenerative Diseases, Amyotrophic Lateral Sclerosis +9

Multicentre appraisal of amyotrophic lateral sclerosis biofluid biomarkers shows primacy of blood neurofilament light chain

Alexander G. Thompson, Elizabeth Gray, Nick Verber et al. · Brain Communications · 2022 · 77 citations · Full text

C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9

Björn F. Vahsen, Sumedha Nalluru, Georgia R. Morgan et al. · Nature Communications · 2023 · 61 citations · Full text

TARDBP pathogenic mutations increase cytoplasmic translocation of TDP-43 and cause reduction of endoplasmic reticulum Ca2+ signaling in motor neurons

Ruxandra Mutihac, Javier Alegre‐Abarrategui, David F. Gordon et al. · Neurobiology of Disease · 2014 · 56 citations · Full text

Tardbp Pathogenic Mutations, Signal Transduction, Motor Neurons +8