Identification of a Titin-Derived HLA-A1–Presented Peptide as a Cross-Reactive Target for Engineered MAGE A3–Directed T Cells

Brian Cameron, Andrew B. Gerry, Joseph Dukes, +27

Science Translational Medicine

Monoclonal TCR-redirected tumor cell killing

Nathaniel Liddy, Giovanna Bossi, Katherine J. Adams, +32

Nature Medicine

Cancer ImmunosurveillanceMedicineTumor ImmunityOncologyCell Biology +1

Different affinity windows for virus and cancer‐specific <scp>T</scp>‐cell receptors: Implications for therapeutic strategies

Milos Aleksic, Nathaniel Liddy, Peter Molloy, +4

European Journal of Immunology

ImmunologyImmunoeditingPathologyAntigen ProcessingImmunotherapeutics +19

Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor

Angel Varela‐Rohena, Peter Molloy, Steven M. Dunn, +16

Nature Medicine

Hiv-1 Immune EscapeAutoimmune DiseaseCd8 T CellsT-regulatory CellHuman Retrovirus +9

The Human CD8 Coreceptor Effects Cytotoxic T Cell Activation and Antigen Sensitivity Primarily by Mediating Complete Phosphorylation of the T Cell Receptor ζ Chain

Marco A. Purbhoo, Jonathan M. Boulter, David A. Price, +9

Journal of Biological Chemistry

Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy

Marine C. C. Raman, P.J. Rizkallah, Ruth Simmons, +13

Scientific Reports

Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors

Emmet McCormack, Katherine J. Adams, Namir J. Hassan, +16

Cancer Immunology Immunotherapy

Lage-1-positive TumorsGfp Fluorescence ReadoutImmunologyImmunoeditingAntigen Processing +17

Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen

Andrew J. Poole, V. Karuppiah, Annabelle Hartt, +22

Nature Communications

Specificity of bispecific T cell receptors and antibodies targeting peptide-HLA

Christopher J. Holland, Rory Crean, Johanne M. Pentier, +26

Journal of Clinical Investigation

An approved in vitro approach to preclinical safety and efficacy evaluation of engineered T cell receptor anti-CD3 bispecific (ImmTAC) molecules

Jane Harper, Katherine J. Adams, Giovanna Bossi, +23

PLoS ONE

Cell TherapyImmunologyImmunoeditingImmunologic MechanismAntigen Processing +18