John F. Gierthy

17β-Estradiol hydroxylation catalyzed by human cytochrome P450 1A1: A comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA

David C. Spink, Hans‐Pietro Eugster, David W. Lincoln et al. · Archives of Biochemistry and Biophysics · 1992 · 243 citations

Molecular Pharmacology, Biochemistry, Medicine +7

The effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on estrogen metabolism in MCF-7 breast cancer cells: Evidence for induction of a novel 17β-estradiol 4-hydroxylase

David C. Spink, Carrie L. Hayes, Nina R. Young et al. · The Journal of Steroid Biochemistry and Molecular Biology · 1994 · 197 citations · Full text

2,3,7,8-Tetrachlorodibenzo-p-dioxin causes an extensive alteration of 17 beta-estradiol metabolism in MCF-7 breast tumor cells.

David C. Spink, D. W. LINCOLN, Herbert W. Dickerman et al. · Proceedings of the National Academy of Sciences · 1990 · 188 citations · Full text

Breast Oncology, Cancer Biology, E2 Metabolism +16

Calculation of 2,3,7,8-TCDD equivalent concentrations of complex environmental contaminant mixtures

George Eadon, Laurence S. Kaminsky, Jay B. Silkworth et al. · Environmental Health Perspectives · 1986 · 119 citations · Full text

Engineering, Complex Mixtures, Air Quality +25

Suppression of estrogen-regulated extracellular tissue plasminogen activator activity of MCF-7 cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

John F. Gierthy, D. W. LINCOLN, M. Boyd Gillespie et al. · PubMed · 1987 · 113 citations

Breast Oncology, Redox Biology, Tumor Biology +18