David C. Spink

17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1.

Carrie L. Hayes, David C. Spink, Barbara C. Spink et al. · Proceedings of the National Academy of Sciences · 1996 · 637 citations

Medicine, Biochemistry, Pharmacology +16

Differential expression of CYP1A1 and CYP1B1 in human breast epithelial cells and breast tumor cells

David C. Spink · Carcinogenesis · 1998 · 308 citations

Medicine, Biochemistry, Oncology +17

17β-Estradiol hydroxylation catalyzed by human cytochrome P450 1A1: A comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA

David C. Spink, Hans‐Pietro Eugster, David W. Lincoln et al. · Archives of Biochemistry and Biophysics · 1992 · 244 citations

Life Sciences, Biochemistry, Toxicology +16

The effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on estrogen metabolism in MCF-7 breast cancer cells: Evidence for induction of a novel 17β-estradiol 4-hydroxylase

David C. Spink, Carrie L. Hayes, Nina R. Young et al. · The Journal of Steroid Biochemistry and Molecular Biology · 1994 · 197 citations · Full text

Medicine, Biochemistry, Pharmacology +16

2,3,7,8-Tetrachlorodibenzo-p-dioxin causes an extensive alteration of 17 beta-estradiol metabolism in MCF-7 breast tumor cells.

David C. Spink, D. W. LINCOLN, Herbert W. Dickerman et al. · Proceedings of the National Academy of Sciences · 1990 · 188 citations

Life Sciences, Biochemistry, Endocrinology +15