Brandt C. Huddle

A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells

Ilana Chefetz, Edward Grimley, Kun Yang et al. · Cell Reports · 2019 · 146 citations · Full text

Medicine, Cancer Biology, Oncology +10

The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma

Min Pan, William C. Wright, Richard H. Chapple et al. · Nature Communications · 2021 · 93 citations · Full text

Medicine, Oncology, Pharmacology +15

Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy

Brandt C. Huddle, Edward Grimley, Cameron D. Buchman et al. · Journal of Medicinal Chemistry · 2018 · 68 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

Tuning the Baird aromatic triplet-state energy of cyclooctatetraene to maximize the self-healing mechanism in organic fluorophores

Avik Kumar Pati, Ouissam El Bakouri, Steffen Jockusch et al. · Proceedings of the National Academy of Sciences · 2020 · 68 citations · Full text

Natural Sciences, Biophysics, Chemistry +17

Design and Application of a High-Throughput, High-Content Screening System for Natural Product Inhibitors of the Human Parasite <i>Trichomonas vaginalis</i>

Jarrod B. King, Adam C. Carter, Wentao Dai et al. · ACS Infectious Diseases · 2019 · 20 citations · Full text

Pharmacy, Infectious Diseases, Pharmacology +17