Hao Lu

Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127

Skye Montoya, Jessie Bourcier, Mark Noviski et al. · Science · 2024 · 148 citations · Full text

Medicine, Molecular Biology, Oncology +15

NRX-0492 degrades wild-type and C481 mutant BTK and demonstrates in vivo activity in CLL patient-derived xenografts

Deyi Zhang, Hailey M. Harris, Jonathan Chen et al. · Blood · 2022 · 29 citations · Full text

Medicine, Molecular Biology, Oncology +7

Kinase Dead BTK Mutations Confer Resistance to Covalent and Noncovalent BTK Inhibitors but Are Susceptible to Clinical Stage BTK Degraders

Skye Montoya, Jessie Bourcier, Meghan C. Thompson et al. · Blood · 2022 · 17 citations

Medicine, Molecular Biology, Pharmacology +15