Concepedia

Kinase Dead BTK Mutations Confer Resistance to Covalent and Noncovalent BTK Inhibitors but Are Susceptible to Clinical Stage BTK Degraders

Skye Montoya, Jessie Bourcier, Meghan C. Thompson, Mark Noviski, May Tan, Eric Wang, Xiaoli Mi, Nivetha Brathaban, Carla Barrientos Risso, Daniel Tsai,

Blood · 2022 · 17 citations · 0 references

Concepts

MedicineMolecular BiologyPharmacologyDrug DiscoveryMolecular PharmacologyMutation AnalysisProtein Kinase CascadesReceptor Tyrosine Kinase SignalingReceptor-ligand InteractionsTherapeutic ResistanceTyrosine Kinase InhibitorsBtk InhibitorsCovalent Kinase InhibitorsKinase Domain MutationsKinase Inhibitor ResistanceKinase InhibitorsKinase Mutation-mediated ResistanceResistance To Tyrosine Kinase Inhibitors