Xiaopeng Sang

Discovery of a 1<i>H</i>-Benzoimidazol-2-yl)-1<i>H</i>-pyridin-2-one (BMS-536924) Inhibitor of Insulin-like Growth Factor I Receptor Kinase with in Vivo Antitumor Activity

Mark D. Wittman, Joan M. Carboni, Ricardo M. Attar et al. · Journal of Medicinal Chemistry · 2005 · 135 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Discovery of a 2,4-Disubstituted Pyrrolo[1,2-<i>f</i>][1,2,4]triazine Inhibitor (BMS-754807) of Insulin-like Growth Factor Receptor (IGF-1R) Kinase in Clinical Development

Mark D. Wittman, Joan M. Carboni, Yang Zheng et al. · Journal of Medicinal Chemistry · 2009 · 94 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9

Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R)

Upender Velaparthi, Mark D. Wittman, Peiying Liu et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 40 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Microwave-assisted synthesis of primary amine HX salts from halides and 7 M ammonia in methanol

Mark G. Saulnier, Kurt Zimmermann, Charles Struzynski et al. · Tetrahedron Letters · 2003 · 26 citations

Natural Sciences, Chemical Engineering, Chemistry +8

2-(1H-Imidazol-4-yl)ethanamine and 2-(1H-pyrazol-1-yl)ethanamine side chain variants of the IGF-1R inhibitor BMS-536924

Mark G. Saulnier, David B. Frennesson, Mark D. Wittman et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 26 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +8