Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins

Helga H.J. Gerets, Karen Tilmant, Brigitte Gerin, +4

Cell Biology and Toxicology

PathologyHeparg CellsOxidative StressInflammationMrna Level +21

The Use of Real-Time Cell Analyzer Technology in Drug Discovery: Defining Optimal Cell Culture Conditions and Assay Reproducibility with Different Adherent Cellular Models

Franck A. Atienzar, Karen Tilmant, Helga H.J. Gerets, +5

SLAS DISCOVERY

EngineeringCell CultureBiomedical EngineeringCellular PhysiologyBioanalysis +20

Selection of cytotoxicity markers for the screening of new chemical entities in a pharmaceutical context: A preliminary study using a multiplexing approach

Helga H.J. Gerets, Étienne Hanon, Miranda Cornet, +4

Toxicology in Vitro

Medicinal ChemistryNew Chemical EntitiesPharmaceutical ResearchAllergyCytotoxicity Markers +12

Predictivity of dog co-culture model, primary human hepatocytes and HepG2 cells for the detection of hepatotoxic drugs in humans

Franck A. Atienzar, Eric Novik, Helga H.J. Gerets, +6

Toxicology and Applied Pharmacology

Dog Co-culture ModelPrimary Human HepatocytesHepatologyMedicineLiver Physiology +11

Determination of Phospholipidosis Potential Based on Gene Expression Analysis in HepG2 Cells

Franck Atienzar, Helga H.J. Gerets, Simon Dufrane, +6

Toxicological Sciences

Evaluation of Impedance-Based Label-Free Technology as a Tool for Pharmacology and Toxicology Investigations

Franck A. Atienzar, Helga H.J. Gerets, Karen Tilmant, +2

Biosensors

Impedance-based Label-free TechnologyBiomedical EngineeringCellular PhysiologyDrug ResistanceElectrical Impedance +20

The automated micronucleus assay for early assessment of genotoxicity in drug discovery

Karen Tilmant, Helga H.J. Gerets, Pierrette De Ron, +4

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Preclinical Drug EvaluationPredictive ToxicologyMedicineAutomated Micronucleus AssayBioanalysis +9

Identification of Specific mRNA Signatures as Fingerprints for Carcinogenesis in Mice Induced by Genotoxic and Nongenotoxic Hepatocarcinogens

Nadine Kossler, Katja Matheis, Nina Ostenfeldt, +4

Toxicological Sciences

Multiplexing Cell Viability Assays

Helga H.J. Gerets, Stéphane Dhalluin, Franck A. Atienzar

Methods in molecular biology

Apoptosis inhibition and ornithine decarboxylase superinduction as early epigenetic events in morphological transformation of Syrian hamster embryo cells exposed to 2-methoxyacetaldehyde, a metabolite of 2-methoxyethanol

Stéphane Dhalluin, Z. Eliáš, O. Poirot, +5

Toxicology Letters

Developmental BiologyAldehyde DehydrogenaseApoptosis InhibitionEarly Epigenetic EventsCell Death +7