Effects of Uric Acid on the NO Production of HUVECs and its Restoration by Urate Lowering Agents

Mutsuo Mishima, Toshihiro Hamada, Nani Maharani, +15

Drug Research

Effects of uric acid on vascular endothelial function from bedside to bench

Naoyuki Otani, Shigeru Toyoda, Masashi Sakuma, +8

Hypertension Research

UrologyRenal FunctionMedicineVascular PharmacologyPhysiology +7

K201 modulates excitation–contraction coupling and spontaneous Ca2+ release in normal adult rabbit ventricular cardiomyocytes

Christopher M. Loughrey, Naoyuki Otani, Tim Seidler, +4

Cardiovascular Research

Uric Acid-Induced Enhancements of Kv1.5 Protein Expression and Channel Activity via the Akt-HSF1-Hsp70 Pathway in HL-1 Atrial Myocytes

Fikri Taufiq, Nani Maharani, Peili Li, +13

Circulation Journal

Impact of Obstructive Sleep Apnoea on Heart Failure with Preserved Ejection Fraction

Takuo Arikawa, Shigeru Toyoda, Akiko Haruyama, +8

Heart Lung and Circulation

Obstructive Sleep ApnoeaSleepHeart FailureCardiovascular DiseasePhysiology +7

K201 (JTV-519) alters the spatiotemporal properties of diastolic Ca2+ release and the associated diastolic contraction during β-adrenergic stimulation in rat ventricular cardiomyocytes

Elspeth B. Elliott, Hisashi Hasumi, Naoyuki Otani, +5

Basic Research in Cardiology

Cardiac MuscleSynaptic TransmissionDiastolic Ca2+ ReleaseCellular PhysiologyDiastolic Function +21

A phase I study to evaluate safety, pharmacokinetics, and pharmacodynamics of respiratory syncytial virus neutralizing monoclonal antibody <scp>MK</scp>‐1654 in healthy Japanese adults

Yuji Orito, Naoyuki Otani, Yuki Matsumoto, +11

Clinical and Translational Science

Respiratory Virus ImmunityImmunologyRespiratory ComplicationsHealthy Japanese AdultsPharmacotherapy +16

Protective Effects of Topiroxostat on an Ischemia-Reperfusion Model of Rat Hearts

Shogo Tanno, Kenshiro Yamamoto, Yasutaka Kurata, +13

Circulation Journal

The uricosuric effects of dihydropyridine calcium channel blockers in vivo using urate under-excretion animal models

Takayuki Hori, Motoshi Ouchi, Naoyuki Otani, +9

Journal of Pharmacological Sciences

Molecular PharmacologyUrological ResearchUrologyPlasma Uric AcidRenal Function +13

Histological evaluation of nintedanib in non-alcoholic steatohepatitis mice

Warinda Susutlertpanya, Hirokazu Wakuda, Naoyuki Otani, +8

Life Sciences

HepatologyMedicineLiver PhysiologyPathologyHistological Evaluation +5