Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities

Donald C. Porter, Elena Farmaki, Serena Altilia, +18

Proceedings of the National Academy of Sciences

Conventional ChemotherapyOncologyCdk8 ExpressionMedicineCancer Biology +9

CDK8/19 Mediator kinases potentiate induction of transcription by NFκB

Mengqian Chen, Jiaxin Liang, Hao Ji, +14

Proceedings of the National Academy of Sciences

Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer

Martina S.J. McDermott, Alexander A. Chumanevich, Chang‐Uk Lim, +10

Oncotarget

CDK8 Selectively Promotes the Growth of Colon Cancer Metastases in the Liver by Regulating Gene Expression of TIMP3 and Matrix Metalloproteinases

Jiaxin Liang, Mengqian Chen, Daniel Hughes, +9

Cancer Research

Androgenic regulation of hedgehog signaling pathway components in prostate cancer cells

Mengqian Chen, Matthew Tanner, Alice C. Levine, +3

Cell Cycle

Prostate Cancer CellsAndrogenic RegulationCancer BiologyTumor BiologySignaling Pathway +14

A novel miR-375-HOXB3-CDCA3/DNMT3B regulatory circuitry contributes to leukemogenesis in acute myeloid leukemia

Laixi Bi, Bin Zhou, Haiying Li, +6

BMC Cancer

The epidermal growth factor receptor (EGFR) is proteolytically modified by the Matriptase–Prostasin serine protease cascade in cultured epithelial cells

Mengqian Chen, Li‐Mei Chen, Chen‐Yong Lin, +1

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Developmental BiologyCancer GrowthCell ProliferationMatrix BiologyCell Growth +5

Effects of Androgen Receptor and Androgen on Gene Expression in Prostate Stromal Fibroblasts and Paracrine Signaling to Prostate Cancer Cells

Matthew Tanner, Charles Welliver, Mengqian Chen, +5

PLoS ONE

Androgen ReceptorLineage PlasticityUrologySystems BiologyDevelopmental Biology +11

CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins

Mengqian Chen, Jing Li, Li Zhang, +19

Nucleic Acids Research

Identifying Cancers Impacted by CDK8/19

Igor B. Roninson, Balázs Győrffy, Zachary T. Mack, +4

Cells

Tumor BiologyCdk19 Mediator KinasesMedicineAcute Myeloid LeukemiaPathology +8