Toxicogenomics directory of chemically exposed human hepatocytes

Marianna Grinberg, Regina Stöber, Karolina Edlund, +37

Archives of Toxicology

HepatologyToxicogenomics DirectoryLiver PhysiologyHepatitisPathology +6

Drug-Induced Endoplasmic Reticulum and Oxidative Stress Responses Independently Sensitize Toward TNFα-Mediated Hepatotoxicity

Lisa Fredriksson, Steven Wink, Bram Herpers, +9

Toxicological Sciences

ApoptosisCell DeathEr StressCell Death MechanismsRedox Biology +15

Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes

Esmee Koedoot, Michiel Fokkelman, Vasiliki-Maria Rogkoti, +13

Nature Communications

Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury

Steven Wink, Steven Hiemstra, S. Huppelschoten, +2

Archives of Toxicology

High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities

Steven Wink, Steven Hiemstra, Bram Herpers, +1

Archives of Toxicology

Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity

Bram Herpers, Steven Wink, Lisa Fredriksson, +5

Archives of Toxicology

Lung InflammationImmunologyRenal InflammationCell DeathToxicological Mechanism +19

Mining a human transcriptome database for chemical modulators of NRF2

John P. Rooney, Brian N. Chorley, Steven Hiemstra, +5

PLoS ONE

Nfe2l2 GeneMolecular BiologyBioinformatics DatabaseGene Expression ProfilingRedox Biology +20

High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability

Steven Hiemstra, Sreenivasa Ramaiahgari, Steven Wink, +10

Archives of Toxicology

High-throughput Confocal ImagingEngineeringStress Response PathwaysAdvanced ImagingPathology +28

Comprehensive Landscape of Nrf2 and p53 Pathway Activation Dynamics by Oxidative Stress and DNA Damage

Steven Hiemstra, Marije Niemeijer, Esmee Koedoot, +7

Chemical Research in Toxicology

Dna DamageLipid PeroxidationApoptosisMolecular BiologyCell Death +14

Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases

Elias Zgheib, Alice Limonciel, Xiaoqi Jiang, +6

Frontiers in Genetics