Concepedia

Neil A. O’Brien

NA

30

Publications

1.8K

Citations

23

H-Index

2004

Active since

Affiliations

University of California, Los Angeles(Current)

St. Vincent's University Hospital

Dublin City University

University College Dublin

Harvard University

Neil A. O’Brien is an author at University of California, Los Angeles specializing in medicine, breast cancer, and cell biology.

ORCID

Top concepts

Publications per year

2004–2023

30

Publications

30

Activated Phosphoinositide 3-Kinase/AKT Signaling Confers Resistance to Trastuzumab but not Lapatinib

Neil A. O’Brien, Brigid C. Browne, Lucy Chow et al. · Molecular Cancer Therapeutics · 2010 · 334 citations

, , +11

Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer

Alexandra Canonici, Merel Gijsen, Maeve Mullooly et al. · Oncotarget · 2013 · 162 citations · Full text

, , +13

Targeting activated PI3K/mTOR signaling overcomes acquired resistance to CDK4/6-based therapies in preclinical models of hormone receptor-positive breast cancer

Neil A. O’Brien, Martina S.J. McDermott, Dylan Conklin et al. · Breast Cancer Research · 2020 · 150 citations · Full text

Targeting PI3K/mTOR Overcomes Resistance to HER2-Targeted Therapy Independent of Feedback Activation of AKT

Neil A. O’Brien, K McDonald, Tong Luo et al. · Clinical Cancer Research · 2014 · 114 citations

Preclinical Activity of Abemaciclib Alone or in Combination with Antimitotic and Targeted Therapies in Breast Cancer

Neil A. O’Brien, Dylan Conklin, Richard P. Beckmann et al. · Molecular Cancer Therapeutics · 2018 · 103 citations · Full text

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