Bethany L. Purnell

(<i>S</i>,<i>S</i>)-<i>trans-</i>Cyclopentane-Constrained Peptide Nucleic Acids. A General Backbone Modification that Improves Binding Affinity and Sequence Specificity

Jonathan K. Pokorski, Mark A. Witschi, Bethany L. Purnell et al. · Journal of the American Chemical Society · 2004 · 79 citations

Life Sciences, Biotechnology, Molecular Biology +14

Novel furano analogues of duocarmycin C1 and C2: design, synthesis, and biological evaluation of seco-iso-Cyclopropylfurano[2,3-e]indoline (seco-iso-CFI) and seco-Cyclopropyltetrahydrofurano[2,3-f]quinoline (seco-CFQ) analogues

Tiffany T. Howard, Brian M. Lingerfelt, Bethany L. Purnell et al. · Bioorganic & Medicinal Chemistry · 2002 · 34 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14

Novel (S)-(-)- and R-(+)-seco-iso-cyclopropylfurano[e]indoline-5,6,7- trimethoxyindole-2-carboxamide (iso-CFI) Analogs of Duocarmycin C2: Synthesis and Biological Evaluation

John A. Hartley, Moses Lee, Konstantinos Kiakos et al. · Medicinal Chemistry · 2006 · 28 citations

Medicine, Medicinal Chemistry, Pharmacology +9

A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties

Stanley Kupchinsky, Sara Centioni, Tiffany T. Howard et al. · Bioorganic & Medicinal Chemistry · 2004 · 21 citations

Pharmacy, Medicinal Chemistry, Pharmacology +10

DNA interstrand crosslinking agents: Synthesis, DNA interactions, and cytotoxicity of dimeric achiral seco-amino-CBI and conjugates of achiral seco-amino-CBI with pyrrolobenzodiazepine (PBD)

Bethany L. Purnell, Atsushi Sato, Amanda O’Kelley et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 16 citations

Medicine, Molecular Biology, Pharmacology +11