Michael Courtney

Cloning and expression of a cDNA coding for the anticoagulant hirudin from the bloodsucking leech, Hirudo medicinalis.

Richard P. Harvey, Eric Degryse, Lenita M. Stefani et al. · Proceedings of the National Academy of Sciences · 1986 · 202 citations · Full text

Genetics, Bacteriology, Molecular Biology +18

Expression of the alpha-1-antitrypsin gene in mononuclear phagocytes of normal and alpha-1-antitrypsin-deficient individuals.

Jean‐François Mornex, A Chytil-Weir, Y. Martinet et al. · Journal of Clinical Investigation · 1986 · 182 citations · Full text

Alpha-1-antitrypsin-deficient Individuals, Immunology, Alpha-1-antitrypsin Gene +19

Aerosol Administration of a Recombinant Adenovirus Expressing CFTR to Cystic Fibrosis Patients: A Phase I Clinical Trial

G. Bellon, Laurence Michel‐Calemard, Danièle Thouvenot et al. · Human Gene Therapy · 1997 · 176 citations

Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of alpha 1-antitrypsin, rendering it ineffective as an inhibitor of neutrophil elastase.

Richard C. Hubbard, Fumitaka Ogushi, G A Fells et al. · Journal of Clinical Investigation · 1987 · 157 citations · Full text

Asthma, Immunology, Cigarette Smokers +16

High-level production of biologically active human alpha 1-antitrypsin in Escherichia coli.

Michael Courtney, Anne Buchwalder, L.H. Tessier et al. · Proceedings of the National Academy of Sciences · 1984 · 140 citations · Full text

Biosynthesis, High-level Production, Protein Function +15