Karine Leclercq

Binding characteristics of brivaracetam, a selective, high affinity SV2A ligand in rat, mouse and human brain: Relationship to anti-convulsant properties

Michel Gillard, B. B. Fuks, Karine Leclercq et al. · European Journal of Pharmacology · 2011 · 248 citations

Medicine, Neuroscience, Pharmacology +11

SV2A protein is a broad-spectrum anticonvulsant target: Functional correlation between protein binding and seizure protection in models of both partial and generalized epilepsy

Rafał M. Kamiński, Alain Matagne, Karine Leclercq et al. · Neuropharmacology · 2007 · 168 citations

Medicine, Neuroscience, Pharmacology +7

Proepileptic phenotype of SV2A‐deficient mice is associated with reduced anticonvulsant efficacy of levetiracetam

Rafał M. Kamiński, Michel Gillard, Karine Leclercq et al. · Epilepsia · 2009 · 115 citations · Full text

Medicine, Neuroscience, Pharmacology +17

A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target

Prashant K. Srivastava, Jonathan van Eyll, Patrice Godard et al. · Nature Communications · 2018 · 106 citations · Full text

Pharmacy, Neuroscience, Systems Biology +13

Low potency and limited efficacy of antiepileptic drugs in the mouse 6 Hz corneal kindling model

Karine Leclercq, Alain Matagne, Rafał M. Kamiński · Epilepsy Research · 2014 · 58 citations

Medicine, Neurology, Pharmacology +10