L Sheppard

Effective chelation of iron in beta thalassaemia with the oral chelator 1,2-dimethyl-3-hydroxypyrid-4-one.

George J. Kontoghiorghes, M. A. Aldouri, A. V. Hoffbrand et al. · BMJ · 1987 · 190 citations · Full text

Medicine, Hematology, Pharmacology +17

1,2-DIMETHYL-3-HYDROXYPYRID-4-ONE, AN ORALLY ACTIVE CHELATOR FOR TREATMENT OF IRON OVERLOAD

GeorgeJ. Kontoghiorghes, L Sheppard, M. A. Aldouri et al. · The Lancet · 1987 · 180 citations · Full text

Medicine, Chemistry, Medicinal Chemistry +10

Pharmacokinetic studies in humans with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one

George J. Kontoghiorghes, John Goddard, A Bartlett et al. · Clinical Pharmacology & Therapeutics · 1990 · 134 citations

Medicine, Clinical Pharmacokinetics, Pharmacology +17

Long‐term trial with the oral iron chelator 1,2‐dimethyl‐3‐hydroxypyrid‐4‐one (L₁) I. IRON CHELATION AND METABOLIC STUDIES

George J. Kontoghiorghes, A Bartlett, A. V. Hoffbrand et al. · British Journal of Haematology · 1990 · 127 citations

Medicine, Pharmacokinetics, Pharmacology +16

Simple synthesis of the potent iron chelators 1-alkyl-3-hydroxy-2-methylpyrid-4-ones

George J. Kontoghiorghes, L Sheppard · Inorganica Chimica Acta · 1987 · 104 citations

Natural Sciences, Chemistry, Medicinal Chemistry +9