Robert T. Gampe

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1<i>H</i>-indol-5-yl)-7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

Jeffrey M. Axten, Jesús R. Medina, Yanhong Feng et al. · Journal of Medicinal Chemistry · 2012 · 601 citations · Full text

Chemoprevention Strategy, Chemical Biology, Pharmaceutical Chemistry +24

Asymmetry in the PPARγ/RXRα Crystal Structure Reveals the Molecular Basis of Heterodimerization among Nuclear Receptors

Robert T. Gampe, Valerie G. Montana, Millard H. Lambert et al. · Molecular Cell · 2000 · 569 citations · Full text

Signal Transduction, Biochemistry, Natural Sciences +8

Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors

H. Eric Xu, Millard H. Lambert, Valerie G. Montana et al. · Proceedings of the National Academy of Sciences · 2001 · 529 citations · Full text

Structural Basis for Androgen Receptor Interdomain and Coactivator Interactions Suggests a Transition in Nuclear Receptor Activation Function Dominance

Bin He, Robert T. Gampe, A.J. Kole et al. · Molecular Cell · 2004 · 289 citations · Full text

Signal Transduction, Molecular Physiology, Coactivator Interactions +11

Oxindole-Based Inhibitors of Cyclin-Dependent Kinase 2 (CDK2):  Design, Synthesis, Enzymatic Activities, and X-ray Crystallographic Analysis

H. Neal Bramson, J. Corona, Stephen T. Davis et al. · Journal of Medicinal Chemistry · 2001 · 267 citations · Full text

Oxindole-based Inhibitors, Oxindole-based Compounds, Ligand Docking +16