Jeroen den Dunnen

C-Type Lectin DC-SIGN Modulates Toll-like Receptor Signaling via Raf-1 Kinase-Dependent Acetylation of Transcription Factor NF-κB

Sonja I. Gringhuis, Jeroen den Dunnen, Manja Litjens et al. · Immunity · 2007 · 566 citations · Full text

Inflammation, Toll-like Receptors, Molecular Immunology +15

Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-κB activation through Raf-1 and Syk

Sonja I. Gringhuis, Jeroen den Dunnen, Manja Litjens et al. · Nature Immunology · 2009 · 468 citations

Transcriptional Regulation, Signal Transduction, Signaling Pathway +13

Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori

Sonja I. Gringhuis, Jeroen den Dunnen, Manja Litjens et al. · Nature Immunology · 2009 · 435 citations

Pulmonary Tuberculosis, Signal Transduction, Mycobacterium Tuberculosis +9

HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells

Sonja I. Gringhuis, Michiel van der Vlist, Linda Berg et al. · Nature Immunology · 2010 · 250 citations

Productive Infection, Human Retrovirus, Innate Immune System +10

High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages

Willianne Hoepel, Hung‐Jen Chen, Chiara E. Geyer et al. · Science Translational Medicine · 2021 · 245 citations · Full text

Immunodeficiencies, Humoral Response, Immunology +21