William H. Haile

Synthesis and Biological Activity of Folic Acid and Methotrexate Analogues Containing <scp>l</scp>-<i>threo</i>-(2<i>S,</i>4<i>S</i>)-4-Fluoroglutamic Acid and <scp>dl</scp>-3,3-Difluoroglutamic Acid

Barry Hart, William H. Haile, Nicholas J. Licato et al. · Journal of Medicinal Chemistry · 1996 · 39 citations · Full text

Medicine, Biochemistry, Pharmacology +11

Design, Synthesis, and Biological Activities of Classical <i>N</i>-{4-[2-(2-Amino-4-ethylpyrrolo[2,3-<i>d</i>]pyrimidin-5-yl)ethyl]benzoyl}-<scp>l</scp>-glutamic Acid and Its 6-Methyl Derivative as Potential Dual Inhibitors of Thymidylate Synthase and Dihydrofolate Reductase and as Potential Antitumor Agents

Aleem Gangjee, Jianming Yu, Roy L. Kisliuk et al. · Journal of Medicinal Chemistry · 2003 · 38 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Mechanism-Based Inhibition of Human Folylpolyglutamate Synthetase: Design, Synthesis, and Biochemical Characterization of a Phosphapeptide Mimic of the Tetrahedral Intermediate

Takashi Tsukamoto, William H. Haile, John J. McGuire et al. · Archives of Biochemistry and Biophysics · 1998 · 32 citations

Life Sciences, Biochemistry, Medicinal Chemistry +13

Potent inhibition of human folylpolyglutamate synthetase by a phosphinic acid mimic of the tetrahedral reaction intermediate

John J. McGuire, William H. Haile, Nadya Valiaeva et al. · Biochemical Pharmacology · 2003 · 17 citations

Life Sciences, Biochemistry, Pharmacology +7

Synthesis and Biological Evaluation of <i>N</i>^α-(4-Amino-4-deoxy-10-methylpteroyl)-<scp>dl</scp>-4,4-difluoroornithine

Takashi Tsukamoto, William H. Haile, John J. McGuire et al. · Journal of Medicinal Chemistry · 1996 · 14 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +11