Tom N. Grammatopoulos

Dopaminergic neuron loss and up‐regulation of chaperone protein mRNA induced by targeted over‐expression of alpha‐synuclein in mouse substantia nigra

Jessie L. St. Martin, Jochen Klucken, Tiago F. Outeiro et al. · Journal of Neurochemistry · 2006 · 187 citations

Life Sciences, Neurobiology, Neuroscience +16

Angiotensin type 1 receptor antagonist losartan, reduces MPTP-induced degeneration of dopaminergic neurons in substantia nigra

Tom N. Grammatopoulos, Susan Jones, Ferogh A. Ahmadi et al. · Molecular Neurodegeneration · 2007 · 169 citations · Full text

Medicine, Neuroscience, Pharmacology +17

Membrane-associated farnesylated UCH-L1 promotes α-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease

Zhihua Liu, Robin K. Meray, Tom N. Grammatopoulos et al. · Proceedings of the National Academy of Sciences · 2009 · 139 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +15

The pesticide rotenone induces caspase‐3‐mediated apoptosis in ventral mesencephalic dopaminergic neurons

Ferogh A. Ahmadi, Daniel A. Linseman, Tom N. Grammatopoulos et al. · Journal of Neurochemistry · 2003 · 129 citations

Life Sciences, Neurobiology, Neuroscience +17

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors

Jeffrey L. Woodhead, William J. Brock, Sharin E. Roth et al. · Toxicological Sciences · 2016 · 91 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17