Issei Ohtsuka

Effect of ER-27856, a novel squalene synthase inhibitor, on plasma cholesterol in rhesus monkeys: comparison with 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors

Hironobu Hiyoshi, Mamoru Yanagimachi, Masashi Ito et al. · Journal of Lipid Research · 2000 · 63 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +15

Effect of the acyl-CoA:cholesterol acyltransferase inhibitor, E5324, on experimental atherosclerosis in rabbits

Hiroshi Tanaka, Issei Ohtsuka, Motoji Kogushi et al. · Atherosclerosis · 1994 · 33 citations

Life Sciences, Biochemistry, Pharmacology +14

Structure-activity relationship of N-[2-(dimethylamino)-6-[3-(5-methyl-4-phenyl-1H-imidazol-1-yl)propoxy]phenyl]-N'-pentylurea and analogs. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity

Teiji Kimura, Yasutaka Takase, Kenji Hayashi et al. · Journal of Medicinal Chemistry · 1993 · 20 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +11

Structure-activity relationship of a series of phenylureas linked to 4-phenylimidazole. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity. 2

Teiji Kimura, Nobuhisa Watanabe, Makoto Matsui et al. · Journal of Medicinal Chemistry · 1993 · 18 citations · Full text

Medicine, Chemistry, Pharmacology +9

Anti-atherosclerotic effect of E5324, an inhibitor of acyl-CoA:cholesterol acyltransferase, in Watanabe heritable hyperlipidemic rabbits

Motoji Kogushi, Hiroshi Tanaka, Issei Ohtsuka et al. · Atherosclerosis · 1996 · 12 citations

Life Sciences, Biochemistry, Pharmacology +15