Prabha Karnachi

Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development

Zhuming Zhang, Xin‐Jie Chu, Jinjun Liu et al. · ACS Medicinal Chemistry Letters · 2013 · 86 citations · Full text

Medicinal Chemistry, Pharmaceutical Chemistry, Chemoprevention Strategy +14

Experimental Error, Kurtosis, Activity Cliffs, and Methodology: What Limits the Predictivity of Quantitative Structure–Activity Relationship Models?

Robert P. Sheridan, Prabha Karnachi, Matthew Tudor et al. · Journal of Chemical Information and Modeling · 2020 · 61 citations

4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: Synthesis and biological evaluation

Terry V. Hughes, Stuart L. Emanuel, Amanda K. Beck et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 45 citations · Full text

Medicine, Vegf-r2 Inhibitors, Rational Drug Design +4

1-Hydroxy-2-pyridinone-based MMP inhibitors: Synthesis and biological evaluation for the treatment of ischemic stroke

Yuemei Zhang, Xiaodong Fan, Devraj Chakaravarty et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 41 citations · Full text

Thrombosis, Ischemic Stroke, Biochemistry +15

β-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: Part 1. Design, synthesis, and lead identification

Shyh‐Ming Yang, Robert H. Scannevin, Bingbing Wang et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 28 citations · Full text

Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Science +12