Mikie Hinata

Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5,6-epoxyeicosatrienoic acid in rats with monoiodoacetate-induced osteoarthritis

Mikie Hinata, Sunao Imai, Takao Sanaki et al. · Pain · 2018 · 35 citations

Medicine, Pharmacology, Molecular Pharmacology +16

Pharmacological evaluation of novel (6-aminopyridin-3-yl)(4-(pyridin-2-yl)piperazin-1-yl) methanone derivatives as TRPV4 antagonists for the treatment of pain

Naoki Tsuno, Akira Yukimasa, Osamu Yoshida et al. · Bioorganic & Medicinal Chemistry · 2017 · 16 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

Discovery of novel 2′,4′-dimethyl-[4,5′-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 2

Naoki Tsuno, Akira Yukimasa, Osamu Yoshida et al. · Bioorganic & Medicinal Chemistry Letters · 2016 · 13 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Discovery of novel 2′,4′-dimethyl-[4,5′-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 1

Naoki Tsuno, Akira Yukimasa, Osamu Yoshida et al. · Bioorganic & Medicinal Chemistry Letters · 2016 · 10 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12