Sarah T. Diepstraten

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

Rachel Thijssen, Sarah T. Diepstraten, Donia M. Moujalled et al. · Blood · 2021 · 128 citations · Full text

Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells

Zilu Wang, Matteo Burigotto, Sabrina Ghetti et al. · Cancer Discovery · 2023 · 79 citations · Full text

Mutant TRP53 exerts a target gene-selective dominant-negative effect to drive tumor development

Brandon J. Aubrey, Ana Janic, Yunshun Chen et al. · Genes & Development · 2018 · 48 citations · Full text

Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers

Sarah T. Diepstraten, Yuan Yin, John E. La Marca et al. · Cancer Cell · 2024 · 39 citations · Full text

The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells

Zilu Wang, Huimin Hu, Luuk Heitink et al. · Cell Death and Differentiation · 2023 · 33 citations · Full text