Darragh Duffy

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

Jérôme Hadjadj, Nader Yatim, Laura Barnabei et al. · Science · 2020 · 3.1K citations · Full text

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Paul Bastard, Lindsey B. Rosen, Qian Zhang et al. · Science · 2020 · 2.8K citations · Full text

Viral Diagnostics, Immunodeficiencies, Viral Immunity +19

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Paul Bastard, Adrian Gervais, Tom Le Voyer et al. · Science Immunology · 2021 · 600 citations · Full text

Mitochondrial double-stranded RNA triggers antiviral signalling in humans

Ashish Dhir, Somdutta Dhir, Lukasz S. Borowski et al. · Nature · 2018 · 597 citations · Full text

Viral Replication, Immunology, Antiviral Response +2

Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations

Hélène Quach, Maxime Rotival, Julien Pothlichet et al. · Cell · 2016 · 498 citations · Full text