Cyclic HIV-1 Protease Inhibitors Derived from Mannitol:  Synthesis, Inhibitory Potencies, and Computational Predictions of Binding Affinities

Johan Hultén, Nicholas M. Bonham, Ulrika Nillroth, +10

Journal of Medicinal Chemistry

Unexpected Binding Mode of a Cyclic Sulfamide HIV-1 Protease Inhibitor

Kristina Bäckbro, Seved Löwgren, Katrin Österlund, +7

Journal of Medicinal Chemistry

Potent Inhibitors of the <i>Plasmodium </i><i>f</i><i>alciparum</i> Enzymes Plasmepsin I and II Devoid of Cathepsin D Inhibitory Activity

Karolina Ersmark, Isabella Feierberg, Sinisa Bjelic, +7

Journal of Medicinal Chemistry

Synthesis and Comparative Molecular Field Analysis (CoMFA) of Symmetric and Nonsymmetric Cyclic Sulfamide HIV-1 Protease Inhibitors

Wesley Schaal, Anna Karlsson, Göran Ahlsén, +9

Journal of Medicinal Chemistry

Design and Synthesis of Plasmepsin I and Plasmepsin II Inhibitors with Activity in <i>Plasmodium </i><i>f</i><i>alciparum</i>-Infected Cultured Human Erythrocytes

Daniel Nöteberg, Elizabeth Hamelink, Johan Hultén, +4

Journal of Medicinal Chemistry

Inhibitors of the <i>C</i>₂-Symmetric HIV-1 Protease:  Nonsymmetric Binding of a Symmetric Cyclic Sulfamide with Ketoxime Groups in the P2/P2‘ Side Chains

Johan Hultén, Hans O. Andersson, Wesley Schaal, +7

Journal of Medicinal Chemistry

Protein AssemblyMolecular BiologyChemical BiologyPharmaceutical ChemistryMedicinal Chemistry +19

Human immunodeficiency virus type 1 proteinase resistance to symmetric cyclic urea inhibitor analogs

U. NILLROTH, Lotta Vrang, Per-Olof Markgren, +3

Antimicrobial Agents and Chemotherapy

Viral ReplicationImmunologyAntiviral DrugDrug ResistanceHuman Retrovirus +18

C2-Symmetric inhibitors of Plasmodium falciparum plasmepsin II: synthesis and theoretical predictions

Karolina Ersmark, Isabella Feierberg, Sinisa Bjelic, +4

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistryC2-symmetric InhibitorsMedicineNatural Sciences +7

P1/P1′ modified HIV protease inhibitors as tools in two new sensitive surface plasmon resonance biosensor screening assays

Mathias Alterman, Hans Sjöbom, Pär Säfsten, +8

European Journal of Pharmaceutical Sciences

BiochemistryMedicineDrug DiscoveryBioanalysisAntiviral Drug Development +5